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  1. Dubbya_B

    PAS Discussed in Daily Mail Article

    A victim of PAS discusses long-term depression and sexual dysfunction since he took Accutane: There are also several other recent events mentioned in the...
  2. Dubbya_B

    FDA Petition to Add Sexual Side Effects to Accutane Drug Label

    ...Just another plea to comment. 7 comments so far and only 3 are from US citizens. I am planning on protesting the FDA's refusal to recognize sexual side effects this winter. Please support this initiative to have sexual side effects added to the drug label in any way you can.
  3. Dubbya_B

    FDA Petition to Add Sexual Side Effects to Accutane Drug Label

    Thanks Flynn! No one else? Only 3 comments so far. This is a shame that barely anyone seems to care enough about getting sexual side effects recognized to bother typing-up a short message on a government website.
  4. Dubbya_B

    FDA Petition to Add Sexual Side Effects to Accutane Drug Label

    RxISK recently submitted a citizens petition to the FDA to add warnings of sexual side effects to the Accutane/Isotretinoin label. A copy of the petition (containing supportive data from adverse event reporting) can be found...
  5. Dubbya_B


    Keep alert for sexual side effects from Lexapro. It is known to cause PSSD. I had a drastic worsening of anorgasmia and numbness while taking sertraline (another SSRI), but luckily, the effects went away after I stopped taking it. It was difficult to deal with in addition to low libido and...
  6. Dubbya_B

    Dubya_B Lab Results

    Some older stuff from early 2000s. Low FSH is a common theme.
  7. Dubbya_B

    Dubya_B Lab Results

    Rhein 24 Hour Urinary Steroid Assay (shows low 5-alpha reduced cortisol metabolite 5a-THF) 24hr Rheins urine analysis provides measurements of THF (tetrahydrocortisol) and 5a-THF (allo-tetrahydrocortisol), and the ratio of 5a-THF to THF ( ie: 5a-THF / THF ) follows the 5alpha reductase...
  8. Dubbya_B

    Dubya_B Lab Results

    Semen Analysis in May 2010 had many aberrations with borderline low fertility Testicular Ultrasound from April 2010 was normal
  9. Dubbya_B

    Dubya_B Lab Results

    February and March 2010
  10. Dubbya_B

    Dubya_B Lab Results

    My labwork: *************************************************************************************** ************************************************************************************** 7/22/2011 at 8:40 am. I had not taken any drugs or supplements that have any hormonal effects for over 6...
  11. Dubbya_B

    Genome-Wide Association Study of Post-Accutane Syndrome

    Genome-Wide Association Study and post-Accutane Symptom Profile: The administrators of and are collaborating on a community-driven genome-wide association study (GWAS) of sufferers of persistent post-drug side-effects from Accutane, Propecia and SSRIs. This is...
  12. Dubbya_B


    Wanted to share these studies describing CRISPR systems that use deactivated CAS9 to induce epigenetic changes. No one can say that it can't be done, or that it hasn't been done yet, any longer! Thanks to axolotl over at propeciahelp for finding these: H.-K. Liao et al., “In Vivo Target Gene...
  13. Dubbya_B

    @flynn Flynn! Where have you been, how have you been, man?

    @flynn Flynn! Where have you been, how have you been, man?
  14. Dubbya_B Now Welcoming PAS Members is now welcoming PAS and PSSD patients as new members. The symptom profile of many of us with post-Accutane syndrome is nearly identical to the core symptom profile of Post-Finasteride Syndrome and overlaps with the sexual and anhedonic symptoms common in...
  15. Dubbya_B

    Lab Results

    Did the doctor have no comment regarding the CBC results!? It almost looks like he has some type of anemia.
  16. Dubbya_B

    Are Sexual Side Effects Now Listed in All EU Countries?

    Last year, the European Medicines Agency determined that "Problems getting or maintaining and erection and lower libido" was to be added to the product information leaflet for isotretinoin/Accutane. Could members from Europe please state if the manufacturers are following this guideline in...
  17. Dubbya_B

    Dubbya_B Test Results

    Rhein 24-HR Urinary Steroid Hormone Profile (Nov 2010) All units are micrograms/24hrs ( in 2525mL volume ) TEST RESULTS REFERENCE RANGE Estrone (E1) 9.0 3-12 Estradiol (E2) 3.5 0-7 Estriol (E3) 6.7 1-16 Total...
  18. Dubbya_B


    Hi Devolution, The great thing about CRISPR/CAS9 systems is that they excel in targeting a certain gene in a specific spot. The CAS9 enzymes used when this technology was emerging often cut near sites with sequences similar to the target. For instance, they would sometimes cut adjacent to a...
  19. Dubbya_B

    Dubbya_B Test Results

    These are my most recent lab test results. As you can see, I have low FSH, high DHEA-S, and feel it is relevant to mention I had a low sperm count the one time I had it tested. It is abnormal to have low FSH with a low sperm count and this is a sign of some type of HPG axis malfunction. My...
  20. Dubbya_B

    Rick Simpson Oil (RSO) Official Thread

    I am one of the ones who tried RSO with no benefit. The dose was titrated up to 1/2 gram per day over the course of 3 months of oil made from (high THC + high CBD) strains and that was all I could tolerate. It wasn't fun and led to arrhythmias that lasted for a couple months after ending the...