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    Is this PAS

    It sounds unusual but is definitely possible. I’ve not heard of anyone who developed PAS like symptoms changing back to normal and then getting worse whilst off the drug.
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    Ideas from a PSSD study

    Thanks for keeping us updated!
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    Dubya_B Lab Results

    Thanks for posting. This is pretty extensive lab work. Its interesting that your FSH is low, this may also account for the low fertility you reported.
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    Anxiety

    Thats interesting to hear. Glad you're feeling better. Thats interesting that you think Bupropion and Buspirone helped with your libido as well. Have you noticed any major side effects from these drugs. If you could, please post this in the what has / hasn't worked thread as well, as it may be...
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    Flynn - Blood Results

    Hi there, yes you have very low FSH levels as I and several PAS sufferers have reported whilst having normal LH levels. I think FSH levels could be of some significance but its hard to say with any certainty yet. I wrote a little bit about a potential link I made between 5 alpha reductase and...
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    Machine Learning-Guided Research on PAS, PFS, ME/CFS and more

    Thanks for posting this, its very interesting and all contributions to the forum are hugely appreciated. I did look into inflammation a little but need to do more research. I remember reading a post where a user linked PFS to inflammation. The only issue I have is, how could inflammation cause...
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    Flynn - Blood Results

    Did you get your Leutinising hormone tested as well. It's quite useful to know both of these test results together. Thanks for letting me know that youore FSH was low. Are you able to post any other blood results, and are you able to post the normal range for your test? No problem if not.
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    Hello, Sorry I have been away the whole of summer and haven't had time to post on the forum...

    Hello, Sorry I have been away the whole of summer and haven't had time to post on the forum. Don't worry. This forum is here to stay for long term. Even if I lose interest, will continue to pay for hosting etc. as I know how important it is for people to have access to this kind of...
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    THEORY - PAS and PSSD/Serotonin Theory - (Serotonin Overactivity - 5HT2C Receptors) - Plausible/Would be Treatable

    Thanks for reporting the side effects. That would be greatly appreciated. You might even want to share some of the info relating Accutane to 5 Alpha reductase and post Finasteride syndrome (PFS). In all honesty, most doctors have no idea what to make of this stuff as they haven't done any...
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    THEORY - PAS and PSSD/Serotonin Theory - (Serotonin Overactivity - 5HT2C Receptors) - Plausible/Would be Treatable

    I also highly recommend you report your side effects to RxISK - https://rxisk.org/report-a-drug-side-effect-2/ You can do this anonymously and they are perhaps the only organisation who is actually recording this data and publishing it. Such as this -...
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    THEORY - PAS and PSSD/Serotonin Theory - (Serotonin Overactivity - 5HT2C Receptors) - Plausible/Would be Treatable

    Yes I felt it was important to try and aggregate some of the information about this in one place. I completely understand when you say that something doesn't feel 'normal'. Hormone tests don't reveal anything and are the standard response of doctors, as in a normal situation, it would indeed...
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    Prof Melcangi - PFS and PSSD

    Prof Melcangi who is the a major researcher for the PFS foundation recently released a paper linking PFS to PSSD. I think he is probably correct, but it seems crazy that nobody is even mentioning PAS or post retinoid sexual dysfunction (PRSD) as there are far clearer links been PFS and PAS then...
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    Cyclope - Blood Results

    Thanks for posting, you also have low FSH like me. Have you ever had DHEA-S tested?
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    THEORY - PAS and PSSD/Serotonin Theory - (Serotonin Overactivity - 5HT2C Receptors) - Plausible/Would be Treatable

    Thanks for your reply, thats very interesting. So did Accutane give you sexual sid effects such as low libido? And bupropion directly helped the libido issues you had? Or did you just have low libido before accutane? Also have you ever reported your sexual side effects anyway?
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    THEORY - PAS and PFS - 5-Alpha Reductase Enzyme - Very Plausible/Currently seems to be the most likely cause of PAS

    No there is always hope as gene expression can potentially be altered in neural cells though it represents a challenge. I have outlined one of the potential cures/treatments that in theory could work. Have a read - https://pasforum.info/threads/plausible-cure-crispr-cas9-gene-editing.21/ This...
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    New Article by RxISK on Cases of Sexual Dysfunction

    If you've ever thought about donating money towards this cause. RxISK is a great organisation to donate to! https://rxisk.org/enduring-sexual-dysfunction-300-cases/
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    GHB - Gammahydroxybutrate

    I haven't got this stuff, I am just sharing information. Prescription will be almost impossible for you to get as you need to be narcoleptic, and even then its difficult to procure. From information online, it appears the easiest method for purchase is to use the dark markets. This involves...
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    THEORY - PAS and PFS - 5-Alpha Reductase Enzyme - Very Plausible/Currently seems to be the most likely cause of PAS

    Yeah the 2.83 fold figure is for 5AR1 not 5AR2. It would only be 5AR2 activity which would affect penile growth, which as you say, if the activity returned to normal after finishing accutane. I'm pretty sure your dick would still grow to its full potential. The study never specified whether...
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    THEORY - PAS and PFS - 5-Alpha Reductase Enzyme - Very Plausible/Currently seems to be the most likely cause of PAS

    Agreed. Though hair loss on accutane is not likely to be related to DHT and some have reported that they have less beard growth after accutane (again this is all anecdotal and I'm yet to see someone who actually lost beard hair for example, so it may just be imagined). Its hard to say how...