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    THEORY - PAS and PFS - 5-Alpha Reductase Enzyme - Very Plausible/Currently seems to be the most likely cause of PAS

    Isotretinoin as shown above is a 5 alpha reductase inhibitor. 5 alpha reductase inhibition leads to an antiandronergic effect. That means less testosteron is converted into Dihydrotestoseron. So we actually need an adrenergic agonist. There are lots of medication who are adrenergic agonists...
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    SHARE YOUR STORY

    I took Accutane when I was 17. I stopped after 4 and a half month because of the side effects. My biggest issue was the intense brain fog I had, where I couldn't articulate myself as well as I used to which led to immense anxiety levels. I also had arthritis in my left jaw. Furthermore I had...