All-trans retinoic acid-induced hypothalamus–pituitary–adrenal hyperactivity involves glucocorticoid receptor dysregulation

Mar 27, 2018
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#1
Not sure if this has been posted elsewhere - seems to say that the HPA axis is affected by Accutane, through glucocorticoid receptor dysregulation, and that mifepristone can reverse it. Mifepristone is an abortion drug. I couldn't work out if the mifepristone needed to be taken indefinitely, or just a one of course.

My issues are definitely in the HPA axis side of things.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030330/
 
Likes: flynn
Mar 10, 2018
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#2
Not sure if this has been posted elsewhere - seems to say that the HPA axis is affected by Accutane, through glucocorticoid receptor dysregulation, and that mifepristone can reverse it. Mifepristone is an abortion drug. I couldn't work out if the mifepristone needed to be taken indefinitely, or just a one of course.

My issues are definitely in the HPA axis side of things.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030330/
Quite a few PFS guys have tried RU486 (Mifepristone) with some documented trials, along with at least one PAS guy. Some people got some benefits, but most got nothing much. I think the doses being used are higher in the HPA study however.

Could still be worth a go, especially if you can get it on prescription. What's absolutely clear is not everyone has been affected in the same way (which is why there is often speculation on multiple sub-types of PFS, PAS etc) so what ones for one, doesn't necessarily work for another.
 
Mar 27, 2018
12
5
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#3
I think you're right, there are sub-types. I wonder if the PFS guys were treating the sexual side effects, or specifically HPA ones? I have found the forum I think, but it won't let me see the thread. Other sites talk of a "HPA reset" over a relatively short period of time.
 

flynn

Administrator
Staff member
Feb 28, 2018
101
74
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#4
Quite a few PFS guys have tried RU486 (Mifepristone) with some documented trials, along with at least one PAS guy. Some people got some benefits, but most got nothing much. I think the doses being used are higher in the HPA study however.

Could still be worth a go, especially if you can get it on prescription. What's absolutely clear is not everyone has been affected in the same way (which is why there is often speculation on multiple sub-types of PFS, PAS etc) so what ones for one, doesn't necessarily work for another.
Did you ever try mifepristone? Have you spoken to any PAS people who have tried it?
 

flynn

Administrator
Staff member
Feb 28, 2018
101
74
28
#5
Not sure if this has been posted elsewhere - seems to say that the HPA axis is affected by Accutane, through glucocorticoid receptor dysregulation, and that mifepristone can reverse it. Mifepristone is an abortion drug. I couldn't work out if the mifepristone needed to be taken indefinitely, or just a one of course.

My issues are definitely in the HPA axis side of things.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030330/
Have you tried mifepristone yet? It could be worth trying ti at 700mg for 7 days.