Fasting

Mar 20, 2019
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14
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#1
Accutane is said to lower 5 alpha reductase type 1. Logic would have you think well what boost the activity of the type 1 enzyme?!

I’LL TELL YOU WHAT!

INSULIN/dose dependent
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946143/

It’s know that fasting also increased LH by 67%
https://www.ncbi.nlm.nih.gov/m/pubmed/2686332/

I did intermittent fasting for a year and then stopped. What I noticed while fasting was return of morning erections, more random boners, better body composition and slightly improved mental clarity and mental toughness or ability to handle stress.

I do not know if this is the solution but I’m going to incorporate it again and see if I notice anything.
 

flynn

Administrator
Staff member
Feb 28, 2018
101
74
28
#2
Fasting could certainly help and I recommend trying it, if you do, please report your results. I remember reading of several people who had tried 2-3 day fasts.

I guess the question is, if PAS really is caused by reduced expression of 5AR1, which is still unknown at this stage. How much has it's expression been reduced? A study showed that 5AR1 had been reduced by a factor of 2.83. Thus if fasting can only increase 5AR1 expression by 1.5 fold, then even though someone may feel better they are unlikely to be back at baseline.

Additionally, its very important to consider where these changes in 5AR1 expression occur. Do they occurs in the brain or the body?
I'm fairly certain that even if fasting could increase the expression of 5AR1 by 10 fold, if it only does this to 5AR1 expression in the liver and muscle etc. but not in the brain. Then I doubt people with PAS would feel much better.
 
Likes: shivgeorge
Mar 20, 2019
29
14
3
#3
Fasting could certainly help and I recommend trying it, if you do, please report your results. I remember reading of several people who had tried 2-3 day fasts.

I guess the question is, if PAS really is caused by reduced expression of 5AR1, which is still unknown at this stage. How much has it's expression been reduced? A study showed that 5AR1 had been reduced by a factor of 2.83. Thus if fasting can only increase 5AR1 expression by 1.5 fold, then even though someone may feel better they are unlikely to be back at baseline.

Additionally, its very important to consider where these changes in 5AR1 expression occur. Do they occurs in the brain or the body?
I'm fairly certain that even if fasting could increase the expression of 5AR1 by 10 fold, if it only does this to 5AR1 expression in the liver and muscle etc. but not in the brain. Then I doubt people with PAS would feel much better.
I agree sometimes I wish I had a time machine haha. I went to my general doctor today and told him my concerns about Accutane but he didn’t offer much feedback so I’m going to find an endo. Will report back here when I do! I’m also going to test prolactin very soon as it’s a good marker for fertility/serotonin and estrogen
 
Likes: shivgeorge
Mar 10, 2018
5
2
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#4
We have all had our human rights impinged upon and we need to fight back.

Emil the MHRA who at reviewing Isotretinoin.

isotretinoin@mhr.gov.uk
june.raine@mhra.gov.uk (CEO)
Leigh.Henderson@mhra.gov.uk (Head of Isotretinoin)

We can't keep letting dermatologists and pharma promote this evil drug as a miracle treatment.

Describe your prescribing experience(where you informed about the side effects, did the dermatologists try other treatments first etc)

Please state your age when you where Isotretinoin and the age you are now.

Give dosage and duration if you have this information( no worries if you can't remember).


We have all had our human rights impinged upon and we need to fight back.

Emil the MHRA who at reviewing Isotretinoin.

isotretinoin@mhr.gov.uk
june.raine@mhra.gov.uk (CEO)
Leigh.Henderson@mhra.gov.uk (Head of Isotretinoin)

We can't keep letting dermatologists and pharma promote this evil drug as a miracle treatment.

Describe your prescribing experience(where you informed about the side effects, did the dermatologists try other treatments first etc)

Please state your age when you where prescribed Isotretinoin and the age you are now.

List all side effects ( the review is mainly reviewing (psychiatric issues, psychosis, suicidal ideation and attempt, suicide without any warning signs, post treatment suicide, sexual dysfunction, infertility and the permanent nature of some of the side effects).

Give a summary of how this drug impacted upon you and your family.

State you concerns about the drug and tell them what you would like to see happen next - for example do you think the drug should be banned for all, banned for under 18's, stricter safeguards and informed consent etc.

Call for research to be carried out to find a cure(victims should not be left hopeless).

Call for compensation.

Call for an independent inquiry (Jeremy Hunt, health select committee hsccom@parliament.uk)

Nearly 1,500 isotretinoin deaths in the US, mostly teenagers.
100 Isotretinoin deaths reported to the MHRA.
Many more deaths and injury not reported.

You don't have to be from the UK to participate in the review.


You can also report all your side effect to FAERS Dashboard FDA(US) and yellow card(UK) or the health regulator in whatever country you live in.

https://www.dailymail.co.uk/health/...s-disturbing-evidence-leave-men-suicidal.html

https://www.dailymail.co.uk/health/...thers-share-shattering-warning-acne-drug.html

Act now!!